PhD Student in Biochemistry/ Cell Biology (f/m/d)
PhD Student in Biochemistry/ Cell Biology (f/m/d)
PhD student in Biochemistry/Cell Biology (f/m/d)
At the Institute of Physiological Chemistry of the TU Dresden in the group of Prof. Dr. Bernd Schröder
The Schröder lab is at the Faculty of Medicine at the Technische Universität Dresden, which is one of the few Elite Universities in Germany, featuring a life sciences focus area and a highly international and collaborative research community.
Our group works on intramembrane proteolysis which links protein degradation with signal transduction and thus represents an important regulatory mechanism for cellular homeostasis. We are especially interested in the SPP/SPPL family of intramembrane proteases comprising Signal peptide peptidase (SPP) and different SPP-like homologues. These proteases cleave specific membrane proteins and by this means contribute to cellular membrane protein homeostasis while acting as regulatory switches at the same time. Over the last years, we have been analysing the function of these enzymes broadly using cell-based experimental systems as well as mice as model organism. Based on these approaches, we could highlight roles of SPP/SPPL proteases in the immune system, atherosclerosis, germ cell development and regulation of glucose metabolism. In the planned PhD project, we want to characterize the substrate spectrum and in vivo function of SPP further. Therefore, the project will combine basic biochemical/cell biological approaches with specific in vivo phenotyping of conditional knockout mice with regard to metabolism and the immune system. The project offers a broad spectrum of experimental techniques being at the interface of answering fundamental biochemical/cell biological questions and characterizing the patho-physiological relevance of the biochemical findings as well as their translational implications.
Your Profile:
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You hold a Masters degree in biochemistry, biology or related subjects
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You have experimental experience in one of the following areas: biochemistry, cell biology, molecular biology, immunology.
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You are a great team worker.
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You enjoy studying fundamental questions in biology and doing science.
We offer:
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An exciting research project with translational relevance
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Ability to learn and apply a broad spectrum of methods
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Integration into a highly motivated team in a well-equipped institute.
Further information:
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https://tu-dresden.de/med/mf/pch/das-institut/arbeitsgruppen/berndschroeder/research
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Mentrup et al. & Schröder, FEBS J 2024
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Mentrup et al. & Schröder, Cell Mol Life Sci 2020
The position funded by the Deutsche Forschungsgemeinschaft (DFG) is available from 1.6.2025 or later. We kindly ask you to apply via our online form to make the selection process faster and more effective. Your application should include your CV, relevant certificates/degrees, a brief summary of your previous scientific experience, a short statement why you chose to apply for this position and, if available, contact information of two referees.
Your contact
Ihre Ansprechpartner
Prof. Dr. Bernd Schröder
Institute of Physiological Chemistry of the TU Dresden
0351 458 6450
